Soft bioelectronics for in vivo neural probes

Soft bioelectronic neural probes. (a) Schematic view of neural probe placement in brain tissue and scalability comparison, (b) Image of neural probe array, (c) Representative average, and (d) clusters of waveforms from 2-10 weeks post-implantation.

Existing high-resolution neural recording devices cannot achieve simultaneous scalability on both spatial and temporal levels due to a trade-off between sensor density and mechanical flexibility. A team lead by Liu, Bertoldi, Kozinsky, and Suo have introduced a three-dimensional (3D) stacking implantable electronic platform, based on perfluorinated dielectric elastomers and tissue-level soft multilayer electrodes, that enables spatiotemporally scalable single-cell neural electrophysiology. The 3D integrated multilayer soft electrode array retains tissue-level flexibility, reduces chronic immune responses when implanted in neural tissues, and reliably tracks electrical activity in a mouse brain over months.

A long-lasting neural probe
Researchers develop implantable device that can record a collection of individual neurons over months

Le Floch, P., S. Zhao, R. Liu, N. Molinari, E. Medina, H. Shen, Z. Wang, J. Kim, H. Sheng, S. Partarrieu, W. Wang, C. Sessler, G. Zhang, H. Park, X. Gong, A. Spencer, J. Lee, T. Ye, X. Tang, X. Wang, K. Bertoldi, N. Lu, B. Kozinsky, Z. Suo, and J. Liu, "3D spatiotemporally scalable in vivo neural probes based on fluorinated elastomers," Nature Nanotechnology 19, 319–329 (2024) open doi in new window open pdf in new window

Jia Liu (Bioengineering), Katia Bertoldi (Mechanical Engineering), Boris Kozinsky (Material Science), and Zhigang Suo (Material Science & Mechanical Engineering)
2023-2024 Harvard MRSEC (DMR-2011754)