Skip to content
 
 

Towards Differentiation in Untethered Microactuators: A Soft Fabrication Strategy

Architected LCE lattices.
Hydrogel-liquid crystal microactuators. Schematic views of shape evolution during (a) stem cell differentiation, and (b) exposing patterned hydrogel shell-liquid crystal droplets to mechanical and chemical stimuli. (c) Microfluidic assembly of hydrogel-LC droplets. (d) Droplets are subjected to different levels of mechanical strain. (e) Texture is patterned on their core surface via rapid dehydration. (f) Magnetic alignment of LC precursors encodes their 3D molecular anisotropy. (g) Simulated (grey) and experimental (red) actuation behavior of rod, dumbbell, and pyramid particles aligned at 0° with respect to their longitudinal axis.

Aizenberg, Bertoldi, and Weitz fabricated hydrogel-liquid crystal micro-actuators with distinct shapes, surface textures, and actuation modes. Mechanical and chemical stimuli are used to deform and transmit geometrical and textural changes to embedded droplets prior to polymerization. By fine-tuning of their assembly, droplets can transform into a diverse array of microparticle geometries, including spindles, rods, pancakes, dumbbells, and pyramids. By rapidly dehydrating and polymerizing the LC-filled droplets in an applied magnetic field, their 3D mesogenic orientation can be controlled resulting in thermally induced shape morphing responses, which are validated via finite element analysis.

Publication:
Wilborn, A.M., H. Almohammadi, P. Qu, Y. Wang, Y. Yang, R. Kay, D. Kim, K. Bertoldi, D.A. Weitz, and J. Aizenberg, "Towards differentiation in untethered microactuators: A soft fabrication strategy," Advanced Materials 37 (51), 2507273 (2025). open doi in new window open accepted manuscript pdf in new window

Joanna Aizenberg (Chemistry and Material Science), Katia Bertoldi (Mechanical Engineering), and
David A. Weitz (Physics & Applied Physics)
2025-2026 Harvard MRSEC (DMR-2011754)